Unique and specific Proteobacteria diversity in urinary microbiota of tolerant kidney transplanted recipients.
Identifieur interne : 000012 ( Main/Exploration ); précédent : 000011; suivant : 000013Unique and specific Proteobacteria diversity in urinary microbiota of tolerant kidney transplanted recipients.
Auteurs : Luc Colas [France] ; Emmanuel F. Mongodin [États-Unis] ; Emmanuel Montassier [France] ; Mélanie Chesneau [France] ; Pierrick Guerif [France] ; Lauren Hittle [États-Unis] ; Magali Giral [France] ; Jonathan S. Bromberg [États-Unis] ; Sophie Brouard [France]Source :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6143 ] ; 2020.
Abstract
Host-microbiota interactions can modulate the immune system both at local and systemic levels, with potential consequences for organ transplantation outcomes. In this study, we hypothesized that differences in the urinary microbiome following kidney transplantation would be associated with posttransplantation status: stable, minimally immunosuppressed, or tolerant. One hundred thirteen urine samples from stable (n = 51), minimally immunosuppressed (n = 19), and spontaneously tolerant (n = 16) patients, paired with age-matched controls (n = 27) were profiled and compared to each other at a taxonomic level with special interest in the immunosuppressive regimen. All comparisons and correlations were adjusted on sex and time posttransplantation. Our results highlighted a unique and specific urinary microbiota associated with spontaneous tolerance characterized by a high diversity and a clear Proteobacteria profile. Finally, we report that this profile is (1) impacted by gender, (2) inversely correlated with immunosuppressive drugs (calcineurin inhibitors and mammalian target of rapamycin inhibitors), and (3) stable in time.
DOI: 10.1111/ajt.15549
PubMed: 31374143
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type="university">Université de Nantes</orgName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Hittle, Lauren" sort="Hittle, Lauren" uniqKey="Hittle L" first="Lauren" last="Hittle">Lauren Hittle</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Giral, Magali" sort="Giral, Magali" uniqKey="Giral M" first="Magali" last="Giral">Magali Giral</name><affiliation wicri:level="4"><nlm:affiliation>Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de 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Mongodin</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Montassier, Emmanuel" sort="Montassier, Emmanuel" uniqKey="Montassier E" first="Emmanuel" last="Montassier">Emmanuel Montassier</name><affiliation wicri:level="4"><nlm:affiliation>MiHAR Lab, Université de Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>MiHAR Lab, Université de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation></author><author><name sortKey="Chesneau, Melanie" sort="Chesneau, Melanie" uniqKey="Chesneau M" first="Mélanie" last="Chesneau">Mélanie Chesneau</name><affiliation wicri:level="4"><nlm:affiliation>Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Guerif, Pierrick" sort="Guerif, Pierrick" uniqKey="Guerif P" first="Pierrick" last="Guerif">Pierrick Guerif</name><affiliation wicri:level="4"><nlm:affiliation>Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Hittle, Lauren" sort="Hittle, Lauren" uniqKey="Hittle L" first="Lauren" last="Hittle">Lauren Hittle</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Giral, Magali" sort="Giral, Magali" uniqKey="Giral M" first="Magali" last="Giral">Magali Giral</name><affiliation wicri:level="4"><nlm:affiliation>Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Bromberg, Jonathan S" sort="Bromberg, Jonathan S" uniqKey="Bromberg J" first="Jonathan S" last="Bromberg">Jonathan S. Bromberg</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Surgery and Microbiology and Immunology, and the Center for Vascular and Inflammatory Diseases, University of Maryland, School of Medicine, Baltimore, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Departments of Surgery and Microbiology and Immunology, and the Center for Vascular and Inflammatory Diseases, University of Maryland, School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Brouard, Sophie" sort="Brouard, Sophie" uniqKey="Brouard S" first="Sophie" last="Brouard">Sophie Brouard</name><affiliation wicri:level="4"><nlm:affiliation>Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author></analytic><series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title><idno type="eISSN">1600-6143</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Host-microbiota interactions can modulate the immune system both at local and systemic levels, with potential consequences for organ transplantation outcomes. In this study, we hypothesized that differences in the urinary microbiome following kidney transplantation would be associated with posttransplantation status: stable, minimally immunosuppressed, or tolerant. One hundred thirteen urine samples from stable (n = 51), minimally immunosuppressed (n = 19), and spontaneously tolerant (n = 16) patients, paired with age-matched controls (n = 27) were profiled and compared to each other at a taxonomic level with special interest in the immunosuppressive regimen. All comparisons and correlations were adjusted on sex and time posttransplantation. Our results highlighted a unique and specific urinary microbiota associated with spontaneous tolerance characterized by a high diversity and a clear Proteobacteria profile. Finally, we report that this profile is (1) impacted by gender, (2) inversely correlated with immunosuppressive drugs (calcineurin inhibitors and mammalian target of rapamycin inhibitors), and (3) stable in time.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">31374143</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-6143</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>01</Month></PubDate></JournalIssue><Title>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</Title><ISOAbbreviation>Am J Transplant</ISOAbbreviation></Journal><ArticleTitle>Unique and specific Proteobacteria diversity in urinary microbiota of tolerant kidney transplanted recipients.</ArticleTitle><Pagination><MedlinePgn>145-158</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ajt.15549</ELocationID><Abstract><AbstractText>Host-microbiota interactions can modulate the immune system both at local and systemic levels, with potential consequences for organ transplantation outcomes. In this study, we hypothesized that differences in the urinary microbiome following kidney transplantation would be associated with posttransplantation status: stable, minimally immunosuppressed, or tolerant. One hundred thirteen urine samples from stable (n = 51), minimally immunosuppressed (n = 19), and spontaneously tolerant (n = 16) patients, paired with age-matched controls (n = 27) were profiled and compared to each other at a taxonomic level with special interest in the immunosuppressive regimen. All comparisons and correlations were adjusted on sex and time posttransplantation. Our results highlighted a unique and specific urinary microbiota associated with spontaneous tolerance characterized by a high diversity and a clear Proteobacteria profile. Finally, we report that this profile is (1) impacted by gender, (2) inversely correlated with immunosuppressive drugs (calcineurin inhibitors and mammalian target of rapamycin inhibitors), and (3) stable in time.</AbstractText><CopyrightInformation>© 2019 The American Society of Transplantation and the American Society of Transplant Surgeons.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Colas</LastName><ForeName>Luc</ForeName><Initials>L</Initials><Identifier Source="ORCID">0000-0001-8226-4250</Identifier><AffiliationInfo><Affiliation>Plateforme Transversale d'Allergologie et d'Immunologie Clinique, Institut du Thorax, CHU de Nantes, Nantes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mongodin</LastName><ForeName>Emmanuel F</ForeName><Initials>EF</Initials><Identifier Source="ORCID">0000-0003-3833-7437</Identifier><AffiliationInfo><Affiliation>Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Montassier</LastName><ForeName>Emmanuel</ForeName><Initials>E</Initials><Identifier Source="ORCID">0000-0002-2313-1172</Identifier><AffiliationInfo><Affiliation>MiHAR Lab, Université de Nantes, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chesneau</LastName><ForeName>Mélanie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guerif</LastName><ForeName>Pierrick</ForeName><Initials>P</Initials><Identifier Source="ORCID">0000-0003-1766-0745</Identifier><AffiliationInfo><Affiliation>Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hittle</LastName><ForeName>Lauren</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giral</LastName><ForeName>Magali</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0001-7641-1592</Identifier><AffiliationInfo><Affiliation>Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bromberg</LastName><ForeName>Jonathan S</ForeName><Initials>JS</Initials><Identifier Source="ORCID">0000-0002-1407-8795</Identifier><AffiliationInfo><Affiliation>Departments of Surgery and Microbiology and Immunology, and the Center for Vascular and Inflammatory Diseases, University of Maryland, School of Medicine, Baltimore, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brouard</LastName><ForeName>Sophie</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0002-6398-1315</Identifier><AffiliationInfo><Affiliation>Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>DIVAT Consortium</CollectiveName><AffiliationInfo><Affiliation>Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>09</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Transplant</MedlineTA><NlmUniqueID>100968638</NlmUniqueID><ISSNLinking>1600-6135</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">clinical research/practice</Keyword><Keyword MajorTopicYN="Y">immunosuppression/immune modulation</Keyword><Keyword MajorTopicYN="Y">kidney transplantation/nephrology</Keyword><Keyword MajorTopicYN="Y">microbiomics</Keyword><Keyword MajorTopicYN="Y">tolerance</Keyword><Keyword MajorTopicYN="Y">translational research/science</Keyword></KeywordList><InvestigatorList><Investigator ValidYN="Y"><LastName>Blancho</LastName><ForeName>Gilles</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Branchereau</LastName><ForeName>Julien</ForeName><Initials>J</Initials></Investigator><Investigator 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ValidYN="Y"><LastName>Garandeau</LastName><ForeName>Claire</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gourraud-Vercel</LastName><ForeName>Caroline</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hourmant</LastName><ForeName>Maryvonne</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kandell</LastName><ForeName>Christine</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Karam</LastName><ForeName>Georges</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kerleau</LastName><ForeName>Clarisse</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Meurette</LastName><ForeName>Aurélie</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Moreau</LastName><ForeName>Anne</ForeName><Initials>A</Initials></Investigator><Investigator 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Mongodin</name></region><name sortKey="Bromberg, Jonathan S" sort="Bromberg, Jonathan S" uniqKey="Bromberg J" first="Jonathan S" last="Bromberg">Jonathan S. Bromberg</name><name sortKey="Hittle, Lauren" sort="Hittle, Lauren" uniqKey="Hittle L" first="Lauren" last="Hittle">Lauren Hittle</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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